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+# Datasource local storage ignored files
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\ No newline at end of file

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\ No newline at end of file

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\ No newline at end of file

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dataset.py

+import numpy as np
+import pandas as pd
+import torch
+from torch.utils import data
+import json
+import collections
+from sklearn.preprocessing import OneHotEncoder
+from subword_nmt.apply_bpe import BPE
+import codecs
+from tqdm import tqdm
+import csv
+
+
+# vocab_path = './ESPF/protein_codes_uniprot.txt'
+# bpe_codes_protein = codecs.open(vocab_path)
+# pbpe = BPE(bpe_codes_protein, merges=-1, separator='')
+# sub_csv = pd.read_csv('./ESPF/subword_units_map_uniprot.csv')
+#
+# idx2word_p = sub_csv['index'].values
+# words2idx_p = dict(zip(idx2word_p, range(0, len(idx2word_p))))
+
+# vocab_path = './ESPF/drug_codes_chembl.txt'
+# bpe_codes_drug = codecs.open(vocab_path)
+# dbpe = BPE(bpe_codes_drug, merges=-1, separator='')
+# sub_csv = pd.read_csv('./ESPF/subword_units_map_chembl.csv')
+#
+# idx2word_d = sub_csv['index'].values
+# words2idx_d = dict(zip(idx2word_d, range(0, len(idx2word_d))))
+
+# max_d = 205
+# max_p = 545
+
+
+def load_vocab(vocab_file):
+    """Loads a vocabulary file into a dictionary."""
+    vocab = collections.OrderedDict()
+    with open(vocab_file, "r", encoding="utf-8") as reader:
+        tokens = reader.readlines()
+    for index, token in enumerate(tokens):
+        token = token.rstrip("\n")
+        vocab[token] = index
+    return vocab
+
+
+def protein2emb_encoder(x, words2idx_p):
+    max_p = 152
+    # t1 = pbpe.process_line(x).split()  # split
+    t1 = x.split(',')
+    try:
+        i1 = np.asarray([words2idx_p[i] for i in t1])  # index
+    except:
+        i1 = np.array([0])
+        # print(x)
+
+    l = len(i1)
+
+    if l < max_p:
+        i = np.pad(i1, (0, max_p - l), 'constant', constant_values=0)
+        input_mask = ([1] * l) + ([0] * (max_p - l))
+    else:
+        i = i1[:max_p]
+        input_mask = [1] * max_p
+
+    return i, np.asarray(input_mask)
+
+
+def drug2emb_encoder(x, dbpe, words2idx_d):
+    max_d = 50
+    # max_d = 100
+    t1 = dbpe.process_line(x)
+    t1 = t1.split()  # split
+    try:
+        i1 = np.asarray([words2idx_d[i] for i in t1])  # index
+    except:
+        i1 = np.array([0])
+        # print(x)
+
+    l = len(i1)
+    print(i1)
+
+    if l < max_d:
+        i = np.pad(i1, (0, max_d - l), 'constant', constant_values=0)
+        input_mask = ([1] * l) + ([0] * (max_d - l))
+
+    else:
+        i = i1[:max_d]
+        input_mask = [1] * max_d
+
+    return i, np.asarray(input_mask)
+
+
+def seq2emb_encoder(input_seq, max_len, vocab):
+    try:
+        ids = np.asarray([vocab[i] for i in input_seq])
+    except:
+        ids = np.array([0])
+
+    l = len(ids)
+    with open('./utils/data_analyse_train.tsv', 'w') as f:
+        tsv = csv.writer(f)
+        tsv.writerow([ids, l, '\n'])
+
+    if l < max_len:
+        ids = np.pad(ids, (0, max_len - l), 'constant', constant_values=0)
+        input_mask = np.array(([1] * l) + ([0] * (max_len - l)))
+    else:
+        ids = ids[:max_len]
+        input_mask = np.array([1] * max_len)
+
+    return ids, input_mask
+
+
+class Data_Encoder(data.Dataset):
+    def __init__(self, train_file, tokenizer_config):
+        'Initialization'
+        self.begin_id = train_file["begin_id"]
+        self.sep_id = train_file["separate_id"]
+        self.max_len = train_file["max_len"]
+        with open(train_file["sps"], 'r') as f:
+            self.sps = f.readlines()
+        with open(train_file["smile"], 'r') as f:
+            self.smile = f.readlines()
+        with open(train_file["affinity"], 'r') as f:
+            self.affinity = f.readlines()
+        self.vocab = load_vocab(tokenizer_config["vocab_file"])
+        bpe_codes_drug = codecs.open(tokenizer_config["vocab_pair"])
+        self.dbpe = BPE(bpe_codes_drug, merges=-1, separator='')
+
+    def __len__(self):
+        'Denotes the total number of samples'
+        return len(self.sps)
+
+    def __getitem__(self, index):
+        'Generates one sample of data'
+        # Select sample
+        # Load data and get label
+        # tokenization
+        d = self.dbpe.process_line(self.smile[index].strip()).split()
+        p = self.sps[index].strip().split(',')
+        y = self.affinity[index].strip()
+
+        input_seq = [self.begin_id] + d + [self.sep_id] + p + [self.sep_id]
+        input, input_mask = seq2emb_encoder(input_seq, self.max_len, self.vocab)
+
+        return input, y
+
+
+if __name__ == "__main__":
+    # local test
+    # dataFolder = './IC50/SPS/train_smile'
+    # with open(dataFolder, 'r') as f:
+    #     train_smi = f.readlines()
+    # drug_smi = train_smi[0]
+    # d_v, input_mask_d = drug2emb_encoder(drug_smi)
+
+    # test load vocab
+    # vocab_file = './ESPF/vocab.txt'
+    # vocab = load_vocab(vocab_file)
+
+    # test train
+    df_train = {"sps": './IC50/SPS/train_sps',
+                "smile": './IC50/SPS/train_smile',
+                "affinity": './IC50/SPS/train_ic50',
+                "vocab_file": './ESPF/vocab.txt',
+                "begin_id": '[CLS]',
+                "separate_id": "[SEP]",
+                "max_len": 256
+                }
+
+    tokenizer_config = {"vocab_file": './ESPF/vocab.txt',
+                        "vocab_pair": './ESPF/drug_codes_chembl.txt'
+                        }
+    params = {'batch_size': 5,
+              'shuffle': False,
+              'num_workers': 0,
+              'drop_last': True}
+    trainset = Data_Encoder(df_train, tokenizer_config)
+    training_generator = data.DataLoader(trainset)
+    for i, (input, affinity) in tqdm(enumerate(training_generator)):
+        print('----------------')

utils/data_analyse_train.tsv

+"[    4   209  1755  3175  6267 15433   911   535  5272     5    25    34
+    19    30    11    28    11    31    21    15    12    44    12    14
+    58    42    11    29    20    27    11    33    17    15    19    34
+    11    18    12    28    11    78    11    47    35    26    11    15
+    70    36    32    27    58    15    11    14    52    11    14    16
+    18    12    57    11    14    19    18    16     5]",69,"
+"

utils/define_vocab.py

+import pandas as pd
+
+
+sub_csv = pd.read_csv('../ESPF/subword_units_map_chembl.csv')
+idx2word_d = sub_csv['index'].values
+# words2idx_d = dict(zip(idx2word_d, range(0, len(idx2word_d))))
+
+with open('../ESPF/vocab76.to', 'r') as f:
+    prot_vocab = f.readlines()
+
+with open('../ESPF/vocab.txt', 'w') as f:
+    for prot in prot_vocab:
+        f.write(prot.strip() + '\n')
+with open('../ESPF/vocab.txt', 'a') as f:
+    for drug in idx2word_d:
+        f.write(drug + '\n')
+